Bacteria from Frog Destroyed Cancer in Mice: Revolutionary Discovery by Japanese Scientists.

According to ТСН: Japanese researchers have discovered a method that could significantly change approaches to cancer treatment. They studied a bacterium from the intestines of Japanese tree frogs that can completely destroy cancerous tumors in mice after a single injection.

Study of the Bacterium Ewingella americana

The team of scientists focused on the bacterium Ewingella americana, isolated from the gut microbiome of amphibians. This interest arose because spontaneous tumors in wild amphibians and reptiles occur very rarely. Even when tumors appear, it is usually related to environments containing pollutants. These animals live longer, can withstand high cellular stress during metamorphosis and regeneration, and inhabit pathogen-rich conditions.

Researchers believe that part of the natural defense against tumors may be associated not only with the cellular characteristics of the animals but also with their gut microbiome. During their study, scientists isolated 45 strains of bacteria, nine of which demonstrated anti-tumor activity. The most impressive was Ewingella americana, obtained from the intestine of the tree frog.

Results of Experiments

In the experiments, the bacterium was administered intravenously to mice with colorectal cancer. 'One injection led to complete disappearance of tumors in all treated animals,' the authors note. Follow-up checks showed that new tumors did not develop following the re-introduction of cancer cells, indicating activation of a lasting immune response.

Mechanistic studies demonstrated that E. americana acts on the principle of a double blow. This bacterium is most active in low-oxygen environments, characteristic of solid tumors. Within 24 hours after administration, its quantity in the tumor increased about 3000 times, without spreading to healthy tissues. Inside the tumor, the bacterium produced toxins that directly destroyed cancer cells.

Safety and Further Research

The team paid special attention to safety. Observations showed that the bacterium was rapidly cleared from the blood within 24 hours. Inflammatory effects were short-lived and disappeared within 72 hours. During two months of monitoring, no organ damage or chronic toxicity was detected in the mice. It was also confirmed that E. americana is sensitive to antibiotics, which allows for the management of potential complications.

Researchers note that results are experimental and obtained from animal models. Although there are common molecular markers between mouse and human tumors, significant differences in the immune system should be considered. This study highlights the great therapeutic potential of the gut microbiome of lower vertebrates and opens new possibilities for the development of natural, non-pathogenic bacterial preparations.

In the future, the team plans to test the action of Ewingella americana on other models of oncological diseases, such as breast cancer, pancreatic cancer, and melanoma, as well as refine optimal methods of administration and dosing. Scientists are also considering the possibility of using such an approach as an adjunct therapy alongside already existing immunotherapy and chemotherapy methods.